Is It Legit?
Partially Supported
2/5
“Creatine helps memory”
CognitionSupplementsMetabolism
2/5 evidence score1 peer-reviewed study
What the science says
An animal study in rats suggests that creatine supplementation can prevent memory impairment induced by guanidinoacetate (GAA) neurotoxicity, by mitigating its effects on energy metabolism, redox state, and glutamate homeostasis.
Full analysis
The primary evidence supporting the claim comes from a single animal study in rats, demonstrating creatine's neuroprotective effects against a specific neurotoxin (GAA) and its ability to prevent associated memory impairment. While promising, these findings are limited by their preclinical nature and cannot be directly extrapolated to human memory enhancement in healthy individuals or those with other forms of cognitive decline. Further human trials are required to establish creatine's efficacy and safety for memory improvement.
Key studies
Cross-talk between guanidinoacetate neurotoxicity, memory and possible neuroprotective role of creatine.
Marques EP et al. · Biochimica et biophysica acta. Molecular basis of disease · 2019
Creatine supplementation in rats completely prevented memory impairment induced by intrastriatal administration of guanidinoacetate (GAA), a neurotoxic compound.
View paper